CHDdatabase

In CHDbase, 1124 genes are linked to CHD susceptibility. The significance of CHD-related genes were prioritized with a gene interaction network approach and 163 core gene set was extracted with k-core decomposition from the network. The table below provides the CHD-related genes with information indicating whether it belongs to the core gene set, network centrality scores, and the number of supporting evidence items. You can rank genes based on your own experience and preference. The expression profile and functional enrichment of CHD-related genes are also shown here.

1124 CHD-related genes

Expression profile of CHD-related genes

CHD-related genes have higher expression levels compared with background genes, especially during fetal development. Expression levels of syndromic genes are higher than those of nonsyndromic genes in the brain (A). However, in the heart, nonsyndromic genes are expressed at significantly higher levels than syndromic genes (B). Furthermore, CHD-related genes tend to broadly-expressed across tissues (C) and developmental stages (D) compared with the background, according to tissue- and time-specificity indexes as defined by Cardoso-Moreira et al. A non-CHD gene set (n = 1124) was randomly selected as the background (gray). TPM, transcripts per million; PCW, post conception week.

Functional enrichment of CHD-related genes

(A) The top 15 significantly enriched Gene Ontology terms (biological process) for CHD-related genes. (B) The top 15 significantly enriched KEGG and Reactome pathways for CHD-related genes. The adjusted P values corrected with Bonferroni step down were -log (base 10) transformed to denote the significance levels. GFR, growth factor receptor.